The Endurance skill in the S.P.E.C.I.A.L. system is a robust and versatile stat that will make you robust and versatile in the wastes. Endurance will help vault dwellers run faster, last longer, resist disease, and be the post-apocalyptic cannibal deviant that you always wanted to be. You and Dogmeat will be chowing down on other survivors in no time!
Are you finding yourself without Endurance? Well, expect fewer food options, less carrying capacity, less sprinting power, and a greater susceptibility to disease. Yuck.